All Missouri Cities by Population 2022
| Rank | City | 2022 Pop. | 2020 Census | Change (Since 2010) | Density (mi) | Area (mi) |
| 1 | 517,750 | 508,090 | 1.9% | 1,644.253 | 314.885 | |
| 2 | 171,112 | 169,176 | 1.14% | 2,076.816 | 82.392 | |
| 3 | 129,804 | 126,254 | 2.81% | 1,979.652 | 65.569 | |
| 4 | 124,247 | 123,011 | 1% | 1,593.092 | 77.991 | |
| 5 | 59,809 | 58,603 | 2.06% | 2,668.049 | 22.417 | |
| 6 | 52,609 | 52,533 | 0.14% | 4,191.63 | 12.551 | |
| 7 | 52,084 | 51,762 | 0.62% | 1,366.74 | 38.108 | |
| 8 | 50,503 | 49,999 | 1.01% | 1,584.351 | 31.876 | |
| 9 | 47,432 | 44,372 | 6.9% | 2,380.073 | 19.929 | |
| 10 | 39,860 | 39,540 | 0.81% | 1,371.674 | 29.059 | |
| 11 | 31,243 | 31,103 | 0.45% | 3,479.64 | 8.979 | |
| 12 | 30,371 | 30,167 | 0.68% | 1,053.41 | 28.831 | |
| 13 | 30,110 | 30,012 | 0.33% | 3,032.379 | 9.929 | |
| 14 | 29,845 | 29,461 | 1.3% | 3,252.882 | 9.175 | |
| 15 | 28,446 | 28,284 | 0.57% | 1,300.096 | 21.88 | |
| 16 | 27,393 | 27,063 | 1.22% | 3,390.352 | 8.08 | |
| 17 | 26,555 | 26,209 | 1.32% | 1,803.001 | 14.728 | |
| 18 | 25,410 | 25,458 | -0.19% | 1,584.348 | 16.038 | |
| 19 | 24,214 | 24,010 | 0.85% | 4,084.768 | 5.928 | |
| 20 | 24,121 | 23,953 | 0.7% | 1,706.41 | 14.136 | |
| 21 | 24,105 | 23,257 | 3.65% | 2,644.85 | 9.114 | |
| 22 | 23,689 | 22,941 | 3.26% | 1,368.347 | 17.312 | |
| 23 | 21,976 | 21,284 | 3.25% | 1,962.894 | 11.196 | |
| 24 | 21,793 | 21,725 | 0.31% | 1,616.696 | 13.48 | |
| 25 | 20,868 | 20,858 | 0.05% | 1,810.742 | 11.525 | |
| 26 | 20,019 | 19,943 | 0.38% | 1,651.065 | 12.125 | |
| 27 | 19,550 | 18,750 | 4.27% | 1,259.195 | 15.526 | |
| 28 | 19,437 | 19,337 | 0.52% | 2,066.357 | 9.406 | |
| 29 | 19,034 | 18,834 | 1.06% | 1,852.51 | 10.275 | |
| 30 | 18,613 | 18,217 | 2.17% | 2,039.535 | 9.126 | |
| 31 | 18,381 | 18,333 | 0.26% | 3,652.592 | 5.032 | |
| 32 | 17,991 | 18,527 | -2.89% | 2,914.935 | 6.172 | |
| 33 | 17,639 | 17,355 | 1.64% | 7,033.549 | 2.508 | |
| 34 | 17,534 | 17,530 | 0.02% | 1,218.832 | 14.386 | |
| 35 | 16,946 | 17,108 | -0.95% | 1,059.946 | 15.988 | |
| 36 | 16,285 | 16,291 | -0.04% | 909.706 | 17.901 | |
| 37 | 16,181 | 15,627 | 3.55% | 2,636.403 | 6.138 | |
| 38 | 16,139 | 15,959 | 1.13% | 700.767 | 23.03 | |
| 39 | 16,065 | 16,225 | -0.99% | 1,222.675 | 13.139 | |
| 40 | 15,933 | 15,955 | -0.14% | 3,630.503 | 4.389 | |
| 41 | 15,825 | 15,481 | 2.22% | 1,472.823 | 10.745 | |
| 42 | 15,750 | 15,522 | 1.47% | 1,351.94 | 11.65 | |
| 43 | 15,121 | 15,013 | 0.72% | 1,032.735 | 14.642 | |
| 44 | 14,604 | 14,500 | 0.72% | 1,546.294 | 9.445 | |
| 45 | 13,954 | 13,806 | 1.07% | 1,378.591 | 10.122 | |
| 46 | 13,745 | 13,783 | -0.28% | 1,069.043 | 12.857 | |
| 47 | 13,439 | 13,031 | 3.13% | 1,555.162 | 8.642 | |
| 48 | 13,116 | 12,686 | 3.39% | 1,694.531 | 7.74 | |
| 49 | 13,062 | 12,638 | 3.35% | 617.009 | 21.17 | |
| 50 | 12,926 | 12,706 | 1.73% | 2,233.155 | 5.788 | |
| 51 | 12,776 | 12,348 | 3.47% | 1,405.483 | 9.09 | |
| 52 | 12,742 | 12,590 | 1.21% | 808.962 | 15.751 | |
| 53 | 12,562 | 12,600 | -0.3% | 1,018.915 | 12.329 | |
| 54 | 12,531 | 12,895 | -2.82% | 3,355.665 | 3.734 | |
| 55 | 12,224 | 12,184 | 0.33% | 921.315 | 13.268 | |
| 56 | 11,938 | 11,646 | 2.51% | 1,135.795 | 10.511 | |
| 57 | 11,455 | 11,469 | -0.12% | 944.47 | 12.128 | |
| 58 | 11,425 | 11,445 | -0.17% | 784.975 | 14.555 | |
| 59 | 10,808 | 10,404 | 3.88% | 810.582 | 13.334 | |
| 60 | 10,802 | 10,406 | 3.81% | 678.12 | 15.929 | |
| 61 | 10,749 | 10,679 | 0.66% | 1,296.653 | 8.29 | |
| 62 | 10,447 | 10,553 | -1% | 965.027 | 10.826 | |
| 63 | 10,431 | 10,515 | -0.8% | 1,489.732 | 7.002 | |
| 64 | 10,365 | 10,633 | -2.52% | 1,626.074 | 6.374 | |
| 65 | 10,155 | 9,985 | 1.7% | 2,323.409 | 4.371 | |
| 66 | 10,141 | 10,121 | 0.2% | 1,026.096 | 9.883 | |
| 67 | 9,716 | 9,576 | 1.46% | 1,141.586 | 8.511 | |
| 68 | 9,208 | 9,174 | 0.37% | 1,004.089 | 9.171 | |
| 69 | 9,025 | 9,107 | -0.9% | 1,265.182 | 7.133 | |
| 70 | 8,909 | 8,777 | 1.5% | 1,109.929 | 8.027 | |
| 71 | 8,658 | 8,504 | 1.81% | 3,125.418 | 2.77 | |
| 72 | 8,621 | 8,555 | 0.77% | 1,058.373 | 8.146 | |
| 73 | 8,553 | 8,587 | -0.4% | 420.566 | 20.337 | |
| 74 | 8,539 | 8,429 | 1.31% | 959.376 | 8.901 | |
| 75 | 8,283 | 8,143 | 1.72% | 1,500.659 | 5.52 | |
| 76 | 8,269 | 8,233 | 0.44% | 4,249.803 | 1.946 | |
| 77 | 8,229 | 8,513 | -3.34% | 1,357.558 | 6.062 | |
| 78 | 8,229 | 8,157 | 0.88% | 1,309.433 | 6.284 | |
| 79 | 8,178 | 8,212 | -0.41% | 910.186 | 8.985 | |
| 80 | 8,078 | 8,228 | -1.82% | 1,628.363 | 4.961 | |
| 81 | 7,939 | 7,927 | 0.15% | 1,102.645 | 7.2 | |
| 82 | 7,892 | 7,964 | -0.9% | 1,027.32 | 7.682 | |
| 83 | 7,622 | 7,458 | 2.2% | 1,461.321 | 5.216 | |
| 84 | 7,496 | 7,414 | 1.11% | 1,261.404 | 5.943 | |
| 85 | 7,429 | 7,117 | 4.38% | 502.401 | 14.787 | |
| 86 | 7,161 | 7,219 | -0.8% | 1,138.69 | 6.289 | |
| 87 | 6,911 | 6,903 | 0.12% | 1,698.776 | 4.068 | |
| 88 | 6,873 | 6,885 | -0.17% | 1,746.264 | 3.936 | |
| 89 | 6,870 | 6,906 | -0.52% | 838.879 | 8.189 | |
| 90 | 6,574 | 6,634 | -0.9% | 2,525.285 | 2.603 | |
| 91 | 6,556 | 6,344 | 3.34% | 1,084.633 | 6.044 | |
| 92 | 6,459 | 6,449 | 0.16% | 1,473.722 | 4.383 | |
| 93 | 6,181 | 6,021 | 2.66% | 1,180.99 | 5.234 | |
| 94 | 6,134 | 6,026 | 1.79% | 1,425.091 | 4.304 | |
| 95 | 6,119 | 5,611 | 9.05% | 1,325.179 | 4.617 | |
| 96 | 6,070 | 5,990 | 1.34% | 2,374.575 | 2.556 | |
| 97 | 6,057 | 6,013 | 0.73% | 984.897 | 6.15 | |
| 98 | 5,862 | 5,832 | 0.51% | 1,150.858 | 5.094 | |
| 99 | 5,823 | 5,621 | 3.59% | 642.365 | 9.065 | |
| 100 | 5,651 | 5,593 | 1.04% | 1,379.527 | 4.096 |