All South Carolina Cities by Population 2022
| Rank | City | 2022 Pop. | 2020 Census | Change (Since 2010) | Density (mi) | Area (mi) |
| 1 | 156,255 | 150,227 | 4.01% | 1,413.381 | 110.554 | |
| 2 | 138,104 | 136,632 | 1.08% | 1,015.476 | 135.999 | |
| 3 | 118,328 | 114,852 | 3.03% | 1,526.813 | 77.5 | |
| 4 | 95,393 | 90,801 | 5.06% | 1,933.45 | 49.338 | |
| 5 | 76,016 | 74,372 | 2.21% | 1,970.069 | 38.585 | |
| 6 | 73,182 | 70,720 | 3.48% | 2,469.083 | 29.639 | |
| 7 | 52,419 | 50,915 | 2.95% | 2,661.938 | 19.692 | |
| 8 | 47,948 | 45,946 | 4.36% | 1,163.383 | 41.214 | |
| 9 | 44,051 | 43,463 | 1.35% | 1,350.092 | 32.628 | |
| 10 | 40,467 | 39,899 | 1.42% | 1,788.665 | 22.624 | |
| 11 | 39,076 | 38,732 | 0.89% | 1,976.862 | 19.767 | |
| 12 | 37,773 | 37,661 | 0.3% | 913.379 | 41.355 | |
| 13 | 37,396 | 35,682 | 4.8% | 1,587.189 | 23.561 | |
| 14 | 37,266 | 35,308 | 5.55% | 1,629.831 | 22.865 | |
| 15 | 32,525 | 32,025 | 1.56% | 1,543.155 | 21.077 | |
| 16 | 30,754 | 27,716 | 10.96% | 591.788 | 51.968 | |
| 17 | 28,390 | 28,106 | 1.01% | 1,957.254 | 14.505 | |
| 18 | 27,263 | 24,521 | 11.18% | 1,399.158 | 19.485 | |
| 19 | 26,399 | 24,849 | 6.24% | 1,149.069 | 22.974 | |
| 20 | 25,092 | 24,724 | 1.49% | 2,300.967 | 10.905 | |
| 21 | 24,985 | 24,379 | 2.49% | 1,218.324 | 20.508 | |
| 22 | 24,708 | 23,568 | 4.84% | 2,086.824 | 11.84 | |
| 23 | 24,378 | 23,354 | 4.38% | 2,641.115 | 9.23 | |
| 24 | 23,542 | 23,222 | 1.38% | 2,227.491 | 10.569 | |
| 25 | 23,507 | 22,921 | 2.56% | 1,886.124 | 12.463 | |
| 26 | 22,409 | 22,545 | -0.6% | 1,372.763 | 16.324 | |
| 27 | 20,791 | 20,325 | 2.29% | 1,974.208 | 10.531 | |
| 28 | 19,798 | 18,790 | 5.36% | 924.92 | 21.405 | |
| 29 | 18,437 | 17,681 | 4.28% | 2,442.574 | 7.548 | |
| 30 | 17,902 | 17,416 | 2.79% | 2,011.888 | 8.898 | |
| 31 | 15,902 | 15,550 | 2.26% | 2,263.45 | 7.026 | |
| 32 | 14,928 | 14,220 | 4.98% | 880.062 | 16.962 | |
| 33 | 14,379 | 13,297 | 8.14% | 1,670.499 | 8.608 | |
| 34 | 14,031 | 13,781 | 1.81% | 835.004 | 16.804 | |
| 35 | 13,874 | 12,832 | 8.12% | 3,068.342 | 4.522 | |
| 36 | 13,857 | 13,607 | 1.84% | 567.257 | 24.428 | |
| 37 | 13,096 | 13,240 | -1.09% | 1,453.801 | 9.008 | |
| 38 | 12,834 | 12,764 | 0.55% | 1,537.475 | 8.347 | |
| 39 | 12,261 | 11,711 | 4.7% | 1,170.046 | 10.479 | |
| 40 | 11,663 | 11,569 | 0.81% | 1,702.724 | 6.85 | |
| 41 | 10,940 | 10,416 | 5.03% | 1,506.502 | 7.262 | |
| 42 | 10,843 | 10,405 | 4.21% | 1,586.013 | 6.837 | |
| 43 | 10,773 | 10,691 | 0.77% | 1,205.341 | 8.938 | |
| 44 | 10,502 | 9,990 | 5.13% | 698.501 | 15.035 | |
| 45 | 10,178 | 9,740 | 4.5% | 1,335.026 | 7.624 | |
| 46 | 9,375 | 9,335 | 0.43% | 954.722 | 9.82 | |
| 47 | 9,000 | 8,850 | 1.69% | 1,144.324 | 7.865 | |
| 48 | 8,657 | 8,503 | 1.81% | 1,020.891 | 8.48 | |
| 49 | 8,446 | 8,460 | -0.17% | 1,310.752 | 6.444 | |
| 50 | 8,430 | 7,788 | 8.24% | 1,784.397 | 4.724 | |
| 51 | 8,377 | 7,473 | 12.1% | 149.281 | 56.116 | |
| 52 | 8,251 | 8,403 | -1.81% | 1,188.191 | 6.944 | |
| 53 | 8,130 | 8,174 | -0.54% | 1,018.925 | 7.979 | |
| 54 | 7,978 | 7,788 | 2.44% | 739.333 | 10.791 | |
| 55 | 7,461 | 7,633 | -2.25% | 742.471 | 10.049 | |
| 56 | 7,382 | 7,446 | -0.86% | 1,265.706 | 5.832 | |
| 57 | 6,987 | 6,671 | 4.74% | 1,539.589 | 4.538 | |
| 58 | 6,759 | 6,173 | 9.49% | 1,063.213 | 6.357 | |
| 59 | 6,610 | 7,020 | -5.84% | 1,079.024 | 6.126 | |
| 60 | 6,350 | 6,448 | -1.52% | 1,436.401 | 4.421 | |
| 61 | 6,304 | 6,384 | -1.25% | 1,191.057 | 5.293 | |
| 62 | 6,121 | 6,149 | -0.46% | 1,319.884 | 4.638 | |
| 63 | 5,749 | 5,903 | -2.61% | 1,076.421 | 5.341 | |
| 64 | 5,574 | 5,544 | 0.54% | 814.48 | 6.844 | |
| 65 | 5,473 | 5,411 | 1.15% | 636.681 | 8.596 | |
| 66 | 5,463 | 5,339 | 2.32% | 236.166 | 23.132 | |
| 67 | 5,320 | 4,772 | 11.48% | 500.529 | 10.629 | |
| 68 | 5,265 | 5,247 | 0.34% | 1,898.164 | 2.774 | |
| 69 | 5,201 | 5,269 | -1.29% | 1,573.373 | 3.306 | |
| 70 | 4,878 | 5,040 | -3.21% | 820.146 | 5.948 | |
| 71 | 4,802 | 4,874 | -1.48% | 772.601 | 6.215 | |
| 72 | 4,632 | 4,652 | -0.43% | 590.642 | 7.842 | |
| 73 | 4,375 | 4,335 | 0.92% | 1,158.974 | 3.775 | |
| 74 | 4,236 | 4,212 | 0.57% | 1,082.927 | 3.912 | |
| 75 | 4,219 | 4,155 | 1.54% | 2,178.884 | 1.936 | |
| 76 | 4,213 | 4,041 | 4.26% | 784.775 | 5.368 | |
| 77 | 4,065 | 4,043 | 0.54% | 1,102.065 | 3.689 | |
| 78 | 4,034 | 4,072 | -0.93% | 1,038.347 | 3.885 | |
| 79 | 4,021 | 4,079 | -1.42% | 959.038 | 4.193 | |
| 80 | 3,898 | 4,026 | -3.18% | 1,270.843 | 3.067 | |
| 81 | 3,832 | 3,878 | -1.19% | 1,305.028 | 2.936 | |
| 82 | 3,704 | 3,686 | 0.49% | 1,054.205 | 3.514 | |
| 83 | 3,702 | 3,758 | -1.49% | 76.582 | 48.34 | |
| 84 | 3,593 | 3,489 | 2.98% | 779.615 | 4.609 | |
| 85 | 3,477 | 3,293 | 5.59% | 808.336 | 4.301 | |
| 86 | 3,440 | 3,388 | 1.53% | 1,216.424 | 2.828 | |
| 87 | 3,386 | 3,366 | 0.59% | 761.104 | 4.449 | |
| 88 | 3,368 | 3,246 | 3.76% | 1,718.107 | 1.96 | |
| 89 | 3,228 | 3,244 | -0.49% | 1,015.036 | 3.18 | |
| 90 | 3,199 | 3,175 | 0.76% | 543.47 | 5.886 | |
| 91 | 3,147 | 3,215 | -2.12% | 974.9 | 3.228 | |
| 92 | 3,124 | 2,990 | 4.48% | 1,973.463 | 1.583 | |
| 93 | 3,116 | 3,186 | -2.2% | 812.384 | 3.836 | |
| 94 | 3,034 | 3,122 | -2.82% | 933.938 | 3.249 | |
| 95 | 2,970 | 3,076 | -3.45% | 830.814 | 3.575 | |
| 96 | 2,934 | 3,024 | -2.98% | 1,255.271 | 2.337 | |
| 97 | 2,825 | 2,877 | -1.81% | 315.549 | 8.953 | |
| 98 | 2,672 | 2,694 | -0.82% | 592.116 | 4.513 | |
| 99 | 2,558 | 2,542 | 0.63% | 202.341 | 12.642 | |
| 100 | 2,536 | 2,694 | -5.86% | 766.13 | 3.31 |